Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.45 |
| ▸ | PPARA | Q07869 | 15/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13440566 | 0.85 | KDM4E (0.43) | PPARGPPARAPPARDCYP1A2MAPT | |
| SCHEMBL13637202 | 0.83 | LTB4R (0.41) | PPARGPPARAPPARDMAPT | |
| SCHEMBL13441377 | 0.80 | PPARD (0.41) | PPARGPPARAPPARDCYP1A2MAPT | |
| SCHEMBL13440840 | 0.79 | PPARD (0.58) | PPARGPPARAPPARDCYP1A2MAPT | |
| SCHEMBL13637152 | 0.78 | PPARG (0.45) | PPARGPPARAPPARDCYP1A2CYP2D6 | |
| SCHEMBL3586096 | 0.77 | PPARA (0.51) | PPARGPPARAPPARDMEN1CYP1A2 | |
| SCHEMBL3575363 | 0.77 | PPARD (0.47) | PPARGPPARAPPARDCYP1A2MAPT | |
| SCHEMBL3587069 | 0.74 | KDM4E (0.46) | PPARGPPARAPPARDCYP1A2MAPT | |
| SCHEMBL3593824 | 0.69 | PPARG (0.51) | PPARGPPARAPPARDCYP1A2MAPT | |
| SCHEMBL13625952 | 0.69 | ALOX5AP (0.45) | PPARGPPARAPPARDCYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |