Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP10 | P09238 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13442137 | 0.79 | MEN1 (0.39) | ALDH1A1FFAR1HDAC1HDAC2HDAC3 | |
| SCHEMBL13637287 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MAPTFFAR1HDAC1 | |
| SCHEMBL13637357 | 0.73 | LTB4R (0.39) | — | |
| SCHEMBL13637284 | 0.72 | FFAR1 (0.39) | ALDH1A1MAPTFFAR1HDAC1 | |
| SCHEMBL13441643 | 0.71 | FFAR1 (0.39) | FFAR1 | |
| SCHEMBL13442143 | 0.71 | PPARG (0.38) | — | |
| SCHEMBL13637279 | 0.64 | PPARD (0.35) | MAPT | |
| SCHEMBL6516216 | 0.62 | LTA4H (0.59) | ALDH1A1MAPTFFAR1HDAC2MMP2 | |
| SCHEMBL13441399 | 0.62 | HDAC1 (0.41) | HDAC1HDAC2HDAC3 | |
| SCHEMBL13637199 | 0.61 | LTB4R (0.42) | ALDH1A1MAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622491-B2 | Type 2 diabetes, atherosclerosis, cardiovascular disease, Syndrome X; carboxylic acids with dialkyldiether or thioether linking groups e.g. {4-[3-(2-Benzotriazol-2-yl-4-chloro-phenoxy)-propoxy]-phenyl}-acetic acid and {4-[3-(2-benzotriazol-2-yl-4-thiophen-2-yl-phenoxy)-propoxy]-phenyl}-acetic acid | METABOLEX INC. (US) | 2009-11-24 | — | — | US | disclosed |