Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628082 | 0.91 | ALDH1A1 (0.46) | ALDH1A1ALDH2ALDH3A1L3MBTL1MAPK1 | |
| SCHEMBL17830711 | 0.80 | ALDH1A1 (0.63) | ALDH1A1ALDH2ALDH3A1CTRB1CUL4A | |
| SCHEMBL13910806 | 0.80 | ALDH1A1 (0.46) | ALDH1A1ALDH2ALDH3A1CTRB1CUL4A | |
| SCHEMBL6316296 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MAPK1RXFP1CYP1A2CYP2C9 | |
| SCHEMBL6316299 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MAPK1RXFP1CYP1A2CYP2C9 | |
| SCHEMBL14876483 | 0.73 | CTRB1 (0.49) | ALDH1A1ALDH2ALDH3A1L3MBTL1MAPK1 | |
| SCHEMBL6317939 | 0.72 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL6317943 | 0.72 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL13627900 | 0.72 | ALDH1A1 (0.69) | ALDH1A1ALDH2ALDH3A1MAPTCA12 | |
| SCHEMBL20083679 | 0.71 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1MAPK1CTRB1CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612065-B2 | Inhibitors of c-JUN N-terminal kinases (JNK) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-03 | — | — | US | disclosed |
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | SALITURO FRANCESCO G | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | MAP3K1, JUN, MAP3K7 | ALDH1A1 4310/4885ALDH2 3451/4885ALDH3A1 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.