Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1102024 | 0.83 | MEN1 (0.64) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL13637929 | 0.83 | SCN3A (0.41) | MEN1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL1102137 | 0.75 | CHRM2 (0.60) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL1102054 | 0.73 | CHRM2 (0.66) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL1102067 | 0.71 | CHRM2 (0.60) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL1091209 | 0.71 | MEN1 (0.64) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL1102115 | 0.69 | CHRM2 (0.52) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL9250671 | 0.68 | ALDH1A1 (0.68) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL1102082 | 0.68 | MEN1 (0.55) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL9974109 | 0.67 | MEN1 (0.64) | MEN1KMT2AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615563-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-10 | — | — | US | disclosed |