Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21924892 | 0.83 | — | — | |
| SCHEMBL11293032 | 0.81 | — | — | |
| SCHEMBL17768600 | 0.81 | BPTF (0.31) | — | |
| SCHEMBL13630796 | 0.81 | CYP1A2 (0.31) | — | |
| SCHEMBL2649843 | 0.81 | PIK3CD (0.32) | — | |
| SCHEMBL25686695 | 0.78 | — | — | |
| SCHEMBL1528250 | 0.78 | — | — | |
| SCHEMBL26814111 | 0.76 | PIK3CD (0.37) | ADRA1DADRA1A | |
| SCHEMBL22095500 | 0.74 | ALDH1A1 (0.40) | — | |
| SCHEMBL27935393 | 0.74 | HSD11B1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820756-B2 | Bradykinin B2 receptor antagonists | Pharvaris Netherlands B.V. (NL) | 2023-11-21 | — | — | US | disclosed |
| US-11820756-B2 | Bradykinin B2 receptor antagonists | Pharvaris Netherlands B.V. (NL) | 2023-11-21 | — | — | US | disclosed |
| EP-3956326-B1 | (R)-3-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | PHARVARIS GMBH (CH) | 2023-06-28 | — | — | EP | disclosed |
| US-20220289730-A1 | (R)-3-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | PHARVARIS GMBH (CH) | 2022-09-15 | — | — | US | disclosed |
| EP-3998259-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | Pharvaris Netherlands B.V. (NL) | 2022-05-18 | — | — | EP | disclosed |
| US-20220135542-A1 | 1-((S)-1-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)ETHYL)-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | PHARVARIS GMBH (CH) | 2022-05-05 | — | — | US | disclosed |
| US-20220135543-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | Pharvaris Netherlands B.V. (NL) | 2022-05-05 | — | — | US | disclosed |
| EP-3713928-B1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | PHARVARIS NETHERLANDS B V (NL) | 2022-01-12 | — | — | EP | disclosed |
| US-20210017158-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | ANALYTICON DISCOVERY GMBH (DE) | 2021-01-21 | — | — | US | disclosed |
| US-10836748-B2 | Bradykinin B2 receptor antagonists | Pharvaris Netherlands B.V. (NL) | 2020-11-17 | — | — | US | disclosed |
| US-20200255405-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | ANALYTICON DISCOVERY GMBH (DE) | 2020-08-13 | — | — | US | disclosed |
| WO-2020150417-A2 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | IFM DUE, INC. (US) | 2020-07-23 | — | — | WO | disclosed |
| EP-3611165-A1 | PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT | Mitsui Chemicals Agro, Inc. (JP) | 2020-02-19 | — | — | EP | disclosed |
| WO-2019101906-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | PHARVARIS B.V. (NL) | 2019-05-31 | — | — | WO | disclosed |
| US-9670228-B2 | Benzoxazepin PI3K inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2017-06-06 | — | — | US | disclosed |
| US-7618987-B2 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MERCK & CO., INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20070191433-A1 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MERCK SHARP & DOHME CORP. | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017158-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | BDKRB2, BDKRB1, VIPR2 | MPO 2779/4885ADRA1D 237/4885ADRA1A 270/4885 |
| US-20220135543-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | BDKRB2, BDKRB1, VIPR2 | MPO 2779/4885ADRA1D 237/4885ADRA1A 270/4885 |
| US-20220289730-A1 | (R)-3-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | BDKRB2, BDKRB1, BRCA1 | MPO 2300/4885ADRA1D 1225/4885ADRA1A 2502/4885 |
| US-10836748-B2 | Bradykinin B2 receptor antagonists | BDKRB2, BDKRB1, VIPR2 | MPO 2322/4885ADRA1D 320/4885ADRA1A 334/4885 |
| US-11820756-B2 | Bradykinin B2 receptor antagonists | BDKRB2, BDKRB1, VIPR2 | MPO 2322/4885ADRA1D 320/4885ADRA1A 334/4885 |
| US-20200255405-A1 | NOVEL BRADYKININ B2 RECEPTOR ANTAGONISTS | BDKRB2, BDKRB1, VIPR2 | MPO 2779/4885ADRA1D 237/4885ADRA1A 270/4885 |
| US-20070191433-A1 | Acylated piperidine derivatives as melanocortin 4-receptor agonists | MC4R, MC5R, MC3R | MPO 2284/4885ADRA1D 41/4885ADRA1A 123/4885 |
| US-20220135542-A1 | 1-((S)-1-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)ETHYL)-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES | BDKRB2, BDKRB1, BRCA1 | MPO 2139/4885ADRA1D 543/4885ADRA1A 1914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.