Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 4/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922571 | 0.89 | GAA (0.46) | KMT2AMEN1GAATLR9PKM | |
| SCHEMBL14113565 | 0.87 | GAA (0.38) | KMT2AMEN1GAATLR9PKM | |
| SCHEMBL12177620 | 0.84 | BRD4 (0.37) | KMT2AMEN1GAATLR9BRD4 | |
| SCHEMBL12177626 | 0.84 | BRD4 (0.37) | KMT2AMEN1GAATLR9BRD4 | |
| SCHEMBL9922207 | 0.83 | CASP6 (0.44) | KMT2AMEN1GAATLR9PKM | |
| SCHEMBL13638363 | 0.83 | BRD4 (0.36) | KMT2AMEN1GAATLR9BRD4 | |
| SCHEMBL13638364 | 0.83 | P2RY12 (0.40) | KMT2AMEN1GAATLR9SCN2A | |
| SCHEMBL9922425 | 0.83 | BRD4 (0.37) | KMT2AMEN1GAATLR9KDM4E | |
| SCHEMBL13638362 | 0.83 | P2RY12 (0.40) | KMT2AMEN1GAATLR9SCN2A | |
| SCHEMBL14228347 | 0.81 | HRH3 (0.37) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |