Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | F9 | P00740 | 3/20 | 0.33 |
| ▸ | F10 | P00742 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922129 | 0.92 | P2RY12 (0.47) | P2RY12ESR1ESR2GAAPPARG | |
| SCHEMBL12177099 | 0.90 | P2RY12 (0.34) | P2RY12BTKSMN1; SMN2SLC2A1 | |
| SCHEMBL9923183 | 0.88 | P2RY12 (0.38) | P2RY12MAPK14BTKNPC1RAB9A | |
| SCHEMBL12177198 | 0.85 | P2RY12 (0.45) | P2RY12PPARG | |
| SCHEMBL14228568 | 0.85 | P2RY12 (0.39) | P2RY12PPARGF10NAMPT | |
| SCHEMBL14228643 | 0.84 | PPARG (0.41) | P2RY12ESR1ESR2GAAPPARG | |
| SCHEMBL12177640 | 0.84 | ESR1 (0.39) | P2RY12ESR1ESR2GAAPPARG | |
| SCHEMBL13638647 | 0.83 | P2RY12 (0.39) | P2RY12ESR1ESR2PPARGNPC1 | |
| SCHEMBL13638369 | 0.83 | ESR1 (0.38) | P2RY12ESR1ESR2GAAPPARG | |
| SCHEMBL13638645 | 0.83 | P2RY12 (0.43) | P2RY12ESR1ESR2PPARGMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |