Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177642 | 0.90 | P2RY12 (0.47) | P2RY12MAPK14ESR1ESR2ATM | |
| SCHEMBL12177098 | 0.89 | P2RY12 (0.34) | P2RY12MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL12177090 | 0.88 | MAPK14 (0.38) | P2RY12MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL9922358 | 0.84 | P2RY12 (0.45) | P2RY12ATM | |
| SCHEMBL14113531 | 0.84 | P2RY12 (0.39) | P2RY12RAB9A | |
| SCHEMBL13638645 | 0.84 | P2RY12 (0.43) | P2RY12MAPK14ESR1ESR2ATM | |
| SCHEMBL14228643 | 0.83 | PPARG (0.41) | P2RY12ESR1ESR2ATMGAA | |
| SCHEMBL12177640 | 0.83 | ESR1 (0.39) | P2RY12ESR1ESR2ATMHPGD | |
| SCHEMBL13638369 | 0.82 | ESR1 (0.38) | P2RY12MAPK14ESR1ESR2ATM | |
| SCHEMBL13638647 | 0.82 | P2RY12 (0.39) | P2RY12ESR1ESR2ATMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |