Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 12/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922617 | 0.92 | FBP1 (0.43) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL9923230 | 0.92 | P2RY12 (0.37) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL13638555 | 0.91 | P2RY12 (0.38) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL13638362 | 0.88 | P2RY12 (0.40) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL14113602 | 0.86 | BRD4 (0.35) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL12177059 | 0.85 | P2RY12 (0.39) | P2RY12CA12CA9BRD4CREBBP | |
| SCHEMBL9922613 | 0.85 | P2RY12 (0.43) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL13638496 | 0.84 | FBP1 (0.41) | FBP1BRD4CREBBPGRM1NLRP3 | |
| SCHEMBL14228632 | 0.83 | P2RY12 (0.42) | P2RY12FBP1CA12CA1CA2 | |
| SCHEMBL12161612 | 0.83 | P2RY12 (0.40) | P2RY12FBP1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |