Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922092 | 0.93 | P2RY12 (0.56) | P2RY12PPARGRAB9ARXFP1NR2E3 | |
| SCHEMBL9922446 | 0.90 | P2RY12 (0.53) | P2RY12KITERCC1FEN1ERCC4 | |
| SCHEMBL12706582 | 0.88 | P2RY12 (0.46) | P2RY12PPARGKITCA12CA1 | |
| SCHEMBL9922096 | 0.87 | P2RY12 (0.47) | P2RY12RXFP1KITERCC1FEN1 | |
| SCHEMBL14113676 | 0.86 | P2RY12 (0.48) | P2RY12RXFP1KITERCC1FEN1 | |
| SCHEMBL13638700 | 0.85 | P2RY12 (0.47) | P2RY12RXFP1KITERCC1FEN1 | |
| SCHEMBL9922100 | 0.85 | P2RY12 (0.48) | P2RY12KITERCC1FEN1ERCC4 | |
| SCHEMBL13638604 | 0.85 | KMT2A (0.40) | P2RY12PPARGRAB9ARXFP1NR2E3 | |
| SCHEMBL13633807 | 0.84 | P2RY12 (0.58) | P2RY12KITERCC1FEN1ERCC4 | |
| SCHEMBL9922330 | 0.82 | P2RY12 (0.62) | P2RY12KITERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |