Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14946877 | 0.83 | NPC1 (0.72) | NPC1RAB9AKMT2ABCHEACHE | |
| SCHEMBL7761239 | 0.83 | NPC1 (0.72) | NPC1RAB9AKMT2ABCHEACHE | |
| SCHEMBL8017184 | 0.83 | NPC1 (0.72) | NPC1RAB9AKMT2ABCHEACHE | |
| SCHEMBL67832 | 0.81 | RIPK1 (0.60) | NPC1RAB9AKMT2ABCHEACHE | |
| SCHEMBL4970598 | 0.78 | AOC3 (0.53) | KMT2AAOC3 | |
| SCHEMBL4969558 | 0.77 | AOC3 (0.48) | NPC1RAB9AKMT2AAOC3FOLH1 | |
| SCHEMBL4969992 | 0.77 | AOC3 (0.48) | NPC1RAB9AKMT2AAOC3FOLH1 | |
| Setogepram SCHEMBL289216 | 0.76 | ALDH1A1 (0.69) | PLA2G4BALDH1A1PTPN11 | |
| Setogepram SCHEMBL29395927 | 0.76 | ALDH1A1 (0.69) | PLA2G4BALDH1A1PTPN11 | |
| SCHEMBL5361863 | 0.76 | AOC3 (0.53) | AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481976-B1 | 8-AZAPROSTAGLANDIN DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2012-11-07 | — | — | EP | disclosed |