Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ATP4A | P20648 | 1/20 | 0.31 |
| ▸ | ATP4B | P51164 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419870 | 0.92 | HSP90AA1 (0.32) | MAPT | |
| SCHEMBL421149 | 0.90 | MEN1 (0.32) | MEN1KMT2AATP4AATP4BNPSR1 | |
| SCHEMBL445551 | 0.89 | MEN1 (0.32) | MEN1KMT2AATP4AATP4B | |
| SCHEMBL445552 | 0.89 | MEN1 (0.32) | MEN1KMT2AATP4AATP4B | |
| SCHEMBL12287233 | 0.86 | ATP4A (0.33) | ATP4AATP4B | |
| SCHEMBL14293305 | 0.85 | — | — | |
| SCHEMBL421429 | 0.83 | GABRA1 (0.32) | MEN1KMT2A | |
| SCHEMBL12832115 | 0.83 | MEN1 (0.32) | MEN1KMT2AATP4AATP4B | |
| SCHEMBL420136 | 0.82 | HSP90AA1 (0.39) | — | |
| SCHEMBL421457 | 0.81 | HSP90AA1 (0.32) | MAPTMEN1KMT2ANPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817295-B1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP (US) | 2012-11-07 | — | — | EP | disclosed |