Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 4/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18914245 | 0.77 | ALDH1A1 (0.39) | KDR | |
| SCHEMBL25743029 | 0.74 | PSMB5 (0.37) | PSMB5ACACBKDR | |
| SCHEMBL21960490 | 0.74 | BRD4 (0.39) | SCN8ASCN10A | |
| SCHEMBL3670650 | 0.73 | L3MBTL1 (0.36) | SCN8ASCN10AKDR | |
| SCHEMBL3377603 | 0.73 | SMN1; SMN2 (0.43) | SCN8ASCN10AKDRMAP2K2MAP2K1 | |
| SCHEMBL590655 | 0.73 | MAP2K1 (0.42) | SCN8ASCN10AKDRMAP2K2MAP2K1 | |
| SCHEMBL12094978 | 0.70 | ASH1L (0.35) | SCN8ASCN10AKDRMAP2K2MAP2K1 | |
| SCHEMBL18551233 | 0.69 | HSD11B1 (0.45) | KDR | |
| SCHEMBL12094977 | 0.69 | KDM4E (0.40) | MAP2K2MAP2K1 | |
| SCHEMBL17313760 | 0.69 | ACACB (0.36) | SCN8ASCN10AACACBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |