Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.66 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17507431 | 0.90 | ERN1 (0.61) | ERN1LTA4HALOX5PTGS1PTGS2 | |
| SCHEMBL17993572 | 0.82 | ERN1 (0.69) | ERN1ALOX5PTGS1PTGS2MAPT | |
| SCHEMBL3601607 | 0.81 | ERN1 (0.76) | ERN1ALDH1A1MAPTGAAKEAP1 | |
| SCHEMBL12767019 | 0.79 | ERN1 (1.00) | ERN1 | |
| SCHEMBL9754394 | 0.73 | ERN1 (0.57) | ERN1ALDH1A1MAPTGAADPP4 | |
| SCHEMBL3964598 | 0.73 | GABRA1 (0.50) | ERN1GABRA1GABRB2PTGS1ALDH1A1 | |
| SCHEMBL18717162 | 0.73 | ERN1 (0.62) | ERN1GABRA1GABRB2ALDH1A1MEN1 | |
| SCHEMBL18717153 | 0.72 | ERN1 (0.56) | ERN1LTA4HALDH1A1MAPTGAA | |
| SCHEMBL5539652 | 0.70 | LTA4H (0.53) | LTA4HALDH1A1MAPTGAAKEAP1 | |
| SCHEMBL18133656 | 0.69 | ERN1 (0.50) | ERN1LTA4HALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532643-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2520561-A1 | IRE-1A Inhibitors | MannKind Corporation (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2008154484-A1 | IRE-1A INHIBITORS | MANNKIND CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |