Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17993572 | 0.84 | ERN1 (0.69) | ERN1DPP4MAPTKDM4EMEN1 | |
| SCHEMBL12980112 | 0.78 | ALDH1A1 (0.41) | ERN1MAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL30159386 | 0.75 | TDP2 (0.41) | ERN1MAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL13037458 | 0.73 | ERN1 (0.46) | ERN1DPP4ALDH1A1RAB9AKDM4E | |
| SCHEMBL9754595 | 0.72 | ERN1 (0.67) | ERN1MAPTALDH1A1RAB9AKDM4E | |
| SCHEMBL13639877 | 0.72 | ERN1 (0.66) | ERN1DPP4MAPTALDH1A1LTA4H | |
| SCHEMBL12767019 | 0.72 | ERN1 (1.00) | ERN1 | |
| SCHEMBL1830920 | 0.72 | ESR2 (0.40) | ERN1ALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL9754394 | 0.71 | ERN1 (0.57) | ERN1DPP4MAPTALDH1A1KDM4E | |
| SCHEMBL9309936 | 0.69 | KDM4E (0.47) | MAPTEDNRAALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150589-A1 | IRE-1A INHIBITORS | MannKind Corporation (US) | 2017-04-05 | — | — | EP | disclosed |