Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1450871 | 0.97 | TDP1 (0.46) | TDP1TP53CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL132865 | 0.95 | TDP1 (0.44) | TDP1TP53CYP1A2CYP2A6ALDH1A1 | |
| Potassium Ion SCHEMBL134597 | 0.95 | TDP1 (0.44) | TDP1TP53CYP1A2CYP2A6ALDH1A1 | |
| Lithium Ion SCHEMBL3901626 | 0.85 | TDP1 (0.34) | TDP1TP53CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL3899907 | 0.83 | TDP1 (0.35) | TDP1TP53CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL538774 | 0.81 | TDP1 (0.34) | TDP1TP53CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL538837 | 0.80 | TDP1 (0.38) | TDP1TP53CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL538969 | 0.78 | TDP1 (0.32) | TDP1TP53CYP2A6ALDH1A1TSHR | |
| SCHEMBL1653617 | 0.77 | TP53 (0.31) | TDP1TP53 | |
| SCHEMBL5080684 | 0.77 | CYP1A2 (0.35) | TDP1TP53CYP1A2CYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 587 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239190-A2 | POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING | Chevron Phillips Chemical Company LP (US) | 2017-11-01 | — | — | EP | claimed |
| EP-1706437-B1 | DUAL METALLOCENE CATALYST FOR PRODUCING FILM RESINS WITH GOOD MACHINE DIRECTION (MD) ELMENDORF TEAR STRENGTH | CHEVRON PHILLIPS CHEMICAL CO (US) | 2016-01-20 | — | — | EP | claimed |
| EP-2235069-B1 | NANO-LINKED METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2015-11-25 | — | — | EP | claimed |
| EP-2231717-B1 | NANO-LINKED METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2015-10-21 | — | — | EP | claimed |
| EP-2231716-B1 | NANO-LINKED METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2014-04-16 | — | — | EP | claimed |
| US-8524626-B2 | Nano-linked metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2013-09-03 | — | — | US | claimed |
| US-8329833-B2 | Nano-linked metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-12-11 | — | — | US | claimed |
| US-20120149855-A1 | Nano-Linked Metallocene Catalyst Compositions and Their Polymer Products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-06-14 | — | — | US | claimed |
| US-8143183-B2 | Nano-linked metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-03-27 | — | — | US | claimed |
| US-20120058886-A1 | Nano-Linked Metallocene Catalyst Compositions and Their Polymer Products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-03-08 | — | — | US | claimed |
| US-6982306-B2 | Stannoxy-substituted metallocene catalysts for olefin and acetylene polymerization | CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. (US) | 2006-01-03 | — | — | US | claimed |
| US-20050288462-A1 | Polymerization catalysts for producing polymers with low levels of long chain branching | CHEVRON PHILIPS CHEMICAL COMPANY, L.P. | 2005-12-29 | — | — | US | claimed |
| US-20050288461-A1 | Polymerization catalysts for producing polymers with low levels of long chain branching | CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. | 2005-12-29 | — | — | US | claimed |
| WO-2005070977-A1 | DUAL METALLOCENE CATALYST FOR PRODUCING FILM RESINS WITH GOOD MACHINE DIRECTION (MD) ELMENDORF TEAR STRENGTH | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2005-08-04 | — | — | WO | claimed |
| WO-2005068519-A2 | CATALYST COMPOSITIONS AND POLYOLEFINS FOR EXTRUSION COATING APPLICATIONS | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2005-07-28 | — | — | WO | claimed |
| US-20050159300-A1 | Dual metallocene catalyst for producing film resins with good machine direction (MD) elmendorf tear strength | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2005-07-21 | — | — | US | claimed |
| US-20050153830-A1 | contact product of a first metallocene compound, a second metallocene compound, a chemically-treated solid oxide, and an organoaluminum compound; useful properties in impact, tear, adhesion, sealing, extruder motor loads and pressures at comparable melt index values, and neck-in and draw-down. | CHEVRON PHILIPS CHEMICAL COMPANY LP | 2005-07-14 | — | — | US | claimed |
| WO-2005052011-A1 | CATALYST COMPOSITIONS FOR PRODUCING POLYOLEFINS IN THE ABSENCE OF COCATALYSTS | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2005-06-09 | — | — | WO | claimed |
| US-20050113243-A1 | Catalyst compositions for producing polyolefins in the absence of cocatalysts | CHEVRON PHILLIPS CHEMICAL COMPANY, LP | 2005-05-26 | — | — | US | claimed |
| US-20050113245-A1 | STANNOXY-SUBSTITUTED METALLOCENE CATALYSTS FOR OLEFIN AND ACETYLENE POLYMERIZATION | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2005-05-26 | — | — | US | claimed |