Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2617445 | 0.92 | SPNS2 (0.35) | SPNS2TLR8NPC1 | |
| SCHEMBL2617361 | 0.92 | SPNS2 (0.35) | SPNS2TLR8NPC1 | |
| SCHEMBL14873623 | 0.89 | SPNS2 (0.34) | SPNS2TLR8NPC1 | |
| SCHEMBL2617249 | 0.86 | SPNS2 (0.33) | SPNS2 | |
| SCHEMBL13644408 | 0.77 | NPC1 (0.36) | SPNS2TLR8NPC1 | |
| SCHEMBL2630583 | 0.76 | SPNS2 (0.32) | SPNS2 | |
| SCHEMBL13637446 | 0.72 | NPC1 (0.35) | TLR8NPC1 | |
| SCHEMBL2617442 | 0.72 | TLR8 (0.36) | TLR8NPC1 | |
| SCHEMBL2617438 | 0.72 | TLR8 (0.36) | TLR8NPC1 | |
| SCHEMBL2617426 | 0.71 | DPP4 (0.35) | SPNS2TLR8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772507-B2 | Imidazole-benzamide anti-cancer agents | CYTOKINETICS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130096315-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | QIAN XIANGPING (US) | 2013-04-18 | — | — | US | disclosed |
| US-20120283287-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283287-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | KIF5B, KIF2C, PLK1 | SPNS2 3558/4885TLR8 4818/4885NPC1 835/4885 |
| US-20130096315-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | KIF5B, KIF2C, PLK1 | SPNS2 3475/4885TLR8 4810/4885NPC1 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.