Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2617438 | 0.85 | TLR8 (0.36) | NPC1TLR8CASP3SENP8SENP7 | |
| SCHEMBL2617442 | 0.85 | TLR8 (0.36) | NPC1TLR8CASP3SENP8SENP7 | |
| SCHEMBL2617426 | 0.80 | DPP4 (0.35) | NPC1TLR8DPP4DHODH | |
| SCHEMBL13644408 | 0.77 | NPC1 (0.36) | NPC1TLR8CASP3SENP8SENP7 | |
| SCHEMBL13643252 | 0.74 | DHODH (0.38) | CASP3SENP8SENP7SENP6DHODH | |
| SCHEMBL13643259 | 0.72 | SPNS2 (0.36) | NPC1TLR8 | |
| SCHEMBL2617249 | 0.71 | SPNS2 (0.33) | DPP4 | |
| SCHEMBL2617361 | 0.71 | SPNS2 (0.35) | NPC1TLR8 | |
| SCHEMBL2617445 | 0.71 | SPNS2 (0.35) | NPC1TLR8 | |
| SCHEMBL13637086 | 0.70 | CENPE (0.36) | NPC1TLR8CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286841-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286841-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | KIF5B, KIF2C, PLK1 | NPC1 835/4885ANPEP 4562/4885ENPEP 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.