Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13647255 | 0.79 | ALDH1A1 (0.38) | MEN1KMT2AMAPTPOLBTDP1 | |
| SCHEMBL5127752 | 0.77 | LMNA (0.43) | POLBNPC1RAB9AADORA2A | |
| SCHEMBL13647162 | 0.75 | ALDH1A1 (0.44) | MEN1KMT2AMAPK8MAPK9MAPK10 | |
| SCHEMBL13647323 | 0.73 | MAPK10 (0.32) | MAPK8MAPK9MAPK10 | |
| SCHEMBL13647184 | 0.72 | SMN1; SMN2 (0.44) | MAPTPOLBNPC1RAB9AMAPK8 | |
| SCHEMBL13647254 | 0.72 | MAPK10 (0.31) | KMT2AMAPK8MAPK9MAPK10KDM4E | |
| SCHEMBL13647186 | 0.72 | GAA (0.42) | MEN1KMT2AMAPTPOLBHPGD | |
| SCHEMBL3840101 | 0.69 | ERCC1 (0.39) | KDM4EHPGDRNASEH1ALDH1A1NPSR1 | |
| SCHEMBL3833902 | 0.68 | ERCC1 (0.60) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL13646996 | 0.68 | ALDH1A1 (0.40) | MEN1KMT2AMAPTPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309566-B1 | DIHYDROXYPYRIMIDINE CARBOXYLIC ACIDS AS VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-10-07 | — | — | EP | disclosed |