Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 12/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541536 | 0.98 | KCNA5 (0.73) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL480997 | 0.98 | KCNA5 (0.73) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL480998 | 0.98 | KCNA5 (0.73) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL12587918 | 0.98 | KCNA5 (0.73) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL1243557 | 0.85 | KCNA5 (0.64) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL1242084 | 0.85 | KCNA5 (1.00) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL12587929 | 0.84 | KCNA5 (1.00) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL12587920 | 0.84 | KCNA5 (1.00) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL12588145 | 0.84 | KCNA5 (0.67) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL10461663 | 0.83 | KCNA5 (0.60) | KCNA5KCNH2CYP2D6CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247771-A1 | PROCESS FOR OBTAINING ENANTIOMERS OF DULOXETINE PRECURSORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-10-01 | — | — | US | disclosed |
| US-20090247771-A1 | PROCESS FOR OBTAINING ENANTIOMERS OF DULOXETINE PRECURSORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-10-01 | — | — | US | disclosed |
| WO-2007098923-A1 | PROCESS FOR OBTAINING ENANTIOMERS OF DULOXETINE PRECURSORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-09-07 | — | — | WO | disclosed |
| EP-1826204-A1 | Process for obtaining enantiomers of duloxetine precursors | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-08-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247771-A1 | PROCESS FOR OBTAINING ENANTIOMERS OF DULOXETINE PRECURSORS | HTR4, OPRM1, SLC6A4 | KCNA5 709/4885KCNH2 1382/4885CYP2D6 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.