Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 10/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 10/20 | 0.59 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL7688676 | 1.00 | ALDH1A1 (0.64) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| Benzoic Acid SCHEMBL9956241 | 1.00 | ALDH1A1 (0.64) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| Benzoic Acid SCHEMBL28388934 | 1.00 | ALDH1A1 (0.64) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| SCHEMBL1866113 | 0.95 | ALDH1A1 (0.70) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| SCHEMBL1866116 | 0.95 | ALDH1A1 (0.70) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| SCHEMBL3391 | 0.95 | ALDH1A1 (0.70) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| SCHEMBL20515564 | 0.93 | ALDH1A1 (0.68) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| SCHEMBL2788016 | 0.93 | MAPT (0.58) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| Methyl Benzoate SCHEMBL29022830 | 0.93 | ADRB2 (0.59) | ALDH1A1ADRB2ADRB1ADRB3PRKCA | |
| Benzyl Benzoate SCHEMBL9296609 | 0.91 | KMT2A (0.64) | ALDH1A1ADRB2ADRB1ADRB3PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1357 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12514842-B2 | Use of a benzoate containing composition to treat neurodegenerative disorders | RUSH UNIVERSITY MEDICAL CENTER (US) | 2026-01-06 | — | — | US | claimed |
| US-12478598-B2 | Compositions including cinnamic acid and methods of use thereof | RUSH UNIVERSITY MEDICAL CENTER (US) | 2025-11-25 | — | — | US | claimed |
| US-12390971-B2 | Process and system for blending a plasticizer with a polysaccharide ester polymer | CELANESE INTERNATIONAL CORPORATION (US) | 2025-08-19 | — | — | US | claimed |
| EP-3999051-B1 | INHALATION DOSAGE FORMS OF GLYCEROL TRIBENZOATE AND/OR GLYCEROL DIBENZOATE FOR USE IN THE TREATMENT OF HUNTINGTON'S DISEASE | UNIV RUSH MEDICAL CENTER (US) | 2025-07-09 | — | — | EP | claimed |
| EP-4558557-A1 | COMPOSITION CONTAINING CELLULOSE ESTER POLYMER WITH ENHANCED MELT STRENGTH AGENT | Celanese International Corporation (US) | 2025-05-28 | — | — | EP | claimed |
| CN-119894971-A | Compositions containing cellulose ester polymers and enhanced melt strength agents | 国际人造丝公司 | 2025-04-25 | — | — | CN | claimed |
| US-12281215-B2 | Plasticizer composition, and sealant/adhesive compositions including the same | Hanwha Solutions Corporation (KR) | 2025-04-22 | — | — | US | claimed |
| US-20250057793-A1 | BENZOIC ACID SALTS FOR TREATMENT OF NERVOUS SYSTEM INJURIES AND DISORDERS | US GOV VETERANS AFFAIRS (US) | 2025-02-20 | — | — | US | claimed |
| CN-118695857-A | Benzoates for the treatment of neurological injuries and disorders | 由退伍军人事务部代表的美国政府 | 2024-09-24 | — | — | CN | claimed |
| WO-2023137146-A9 | CELLULOSE ESTER COMPOSITION AND PROCESS FOR PRODUCING ARTICLES THEREFROM | CELANESE INTERNATIONAL CORPORATION (US) | 2024-05-23 | — | — | WO | claimed |
| EP-0455373-A1 | Nail enamels containing glyceryl triesters | Revlon Consumer Products Corporation (US) | 1991-11-06 | — | — | EP | claimed |
| US-4931095-A | Benzoate inks | HOWTEK, INC. (US) | 1990-06-05 | — | — | US | claimed |
| US-4551507-A | Polyester composition containing tertiary and quaternary amine carboxylate salts | ALLIED CORPORATION (US) | 1985-11-05 | — | — | US | claimed |
| US-4357268-A | NEUTRALIZED DIMER OR TRIMER ACID | ALLIED CORPORATION (US) | 1982-11-02 | — | — | US | claimed |
| US-4340526-A | ESTER PLASTICIZERS TO LOWER THE MELT VISCOSITY | EASTMAN KODAK COMPANY (US) | 1982-07-20 | — | — | US | claimed |
| US-4303717-A | OXYALKYLATED ALCOHOL | COMMERCIAL DECAL, INC. (US) | 1981-12-01 | — | — | US | claimed |
| US-4172824-A | PLASTICIZER | EASTMAN KODAK COMPANY (US) | 1979-10-30 | — | — | US | claimed |
| US-4151132-A | VIDEO DISCS | RCA CORPORATION (US) | 1979-04-24 | — | — | US | claimed |
| US-4117182-A | ALIPHATIC OXYALKYLATED ALCOHOL, HEAT ACTIVATABLE ADHESIVE | COMMERCIAL DECAL, INC. (US) | 1978-09-26 | — | — | US | claimed |
| US-4068033-A | Heat-releasable decalcomanias and adhesive composition therefor | COMMERCIAL DECAL, INC. (US) | 1978-01-10 | — | — | US | claimed |