SCHEMBL379230

SCHEMBL379230

Nc1ccc2c(c1)CCO2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.56
DYRK1A Q13627 3/20 0.56
MAPT P10636 5/20 0.52
GAA P10253 2/20 0.52
KDM4E B2RXH2 1/20 0.52
RAB9A P51151 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
LMNA P02545 2/20 0.46
NPC1 O15118 2/20 0.46
DYRK2 Q92630 1/20 0.45
DYRK1B Q9Y463 1/20 0.45
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29364809 1.00 PRKCI (0.56) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL29739511 0.88 PRKCI (0.49) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL266080 0.88 PRKCI (0.49) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL22239364 0.86 PRKCI (0.47) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL20330514 0.84 PRKCI (0.46) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL20330515 0.84 PRKCI (0.46) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL655314 0.83 MAPT (0.52) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL978675 0.80 DYRK1A (0.62) PRKCIDYRK1AMAPTRAB9ASMN1; SMN2
SCHEMBL31409240 0.80 HDAC3 (0.50) PRKCIDYRK1AMAPTGAAKDM4E
SCHEMBL1122456 0.79 MAPT (0.40) PRKCIDYRK1AMAPTGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 511 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107743483-B NADPH oxidase 4 inhibitors 埃科特莱茵药品有限公司 2022-01-28 CN claimed
US-20210395238-A1 NADPH OXIDASE 4 INHIBITORS ACTELTION PHARMACEUTICALS LTD (CH) 2021-12-23 US claimed
US-11136317-B2 NADPH oxidase 4 inhibitors ACTELION PHARMACEUTICALS LTD (CH) 2021-10-05 US claimed
EP-3310767-B1 2,5-DISUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AS NADPH OXIDASE 4 INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2020-07-22 EP claimed
US-20200165235-A1 NADPH OXIDASE 4 INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2020-05-28 US claimed
US-10584118-B2 NADPH oxidase 4 inhibitors ACTELION PHARMACEUTICALS LTD (CH) 2020-03-10 US claimed
US-20180179194-A1 NADPH OXIDASE 4 INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2018-06-28 US claimed
EP-3310767-A1 NADPH OXIDASE 4 INHIBITORS Actelion Pharmaceuticals Ltd. (CH) 2018-04-25 EP claimed
WO-2016207785-A1 NADPH OXIDASE 4 INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2016-12-29 WO claimed
EP-2475644-B1 HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES HOFFMANN LA ROCHE (CH) 2014-01-08 EP claimed
US-8258158-B2 HSL inhibitors useful in the treatment of diabetes HOFFMANN-LA ROCHE INC. (US) 2012-09-04 US claimed
EP-2475644-A1 HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES F. Hoffmann-La Roche AG (CH) 2012-07-18 EP claimed
WO-2011029808-A1 HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2011-03-17 WO claimed
US-20110065707-A1 NEW HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES HOFFMANN-LA ROCHE, INC. 2011-03-17 US claimed
US-20260138985-A1 Azepino-Indoles for the Treatment of Neurological and Psychiatric Disorders TERRAN BIOSCIENCES INC (US) 2026-05-21 US disclosed
US-20260138990-A1 TRICYCLIC FUSED IMIDAZOLE COMPOUNDS AS CD38 MODULATORS AND USES THEREOF AEOVIAN PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
EP-4702026-A1 TRICYCLIC FUSED IMIDAZOLE COMPOUNDS AS CD38 MODULATORS AND USES THEREOF Aeovian Pharmaceuticals, Inc. (US) 2026-03-04 EP disclosed
US-4411910-A Benzofuran derivatives and their pharmaceutical use SCHERING AKTIENGESELLSCHAFT (DE) 1983-10-25 US disclosed
EP-0059884-A1 Benzofurane derivatives, their preparation and use SCHERING AKTIENGESELLSCHAFT (DE) 1982-09-15 EP disclosed
US-3963717-A ANTIINFLAMMATORY, ANALGESIC SANDOZ, INC. (US) 1976-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260138990-A1 TRICYCLIC FUSED IMIDAZOLE COMPOUNDS AS CD38 MODULATORS AND USES THEREOF CD38, BCL9, BCL6B PRKCI 1973/4885DYRK1A 2437/4885MAPT 4130/4885
US-20260138985-A1 Azepino-Indoles for the Treatment of Neurological and Psychiatric Disorders TPH2, TPH1, HTR1D PRKCI 2581/4885DYRK1A 236/4885MAPT 1145/4885
US-10584118-B2 NADPH oxidase 4 inhibitors NOX4, NOX1, CYBB PRKCI 2510/4885DYRK1A 3287/4885MAPT 2832/4885
US-20200165235-A1 NADPH OXIDASE 4 INHIBITORS NOX4, NOX1, CYBB PRKCI 2510/4885DYRK1A 3287/4885MAPT 2832/4885
US-20110065707-A1 NEW HSL INHIBITORS USEFUL IN THE TREATMENT OF DIABETES LIPE, PNLIP, LPL PRKCI 2341/4885DYRK1A 3216/4885MAPT 4639/4885
US-11136317-B2 NADPH oxidase 4 inhibitors NOX4, NOX1, CYBB PRKCI 2510/4885DYRK1A 3287/4885MAPT 2832/4885
US-20180179194-A1 NADPH OXIDASE 4 INHIBITORS NOX4, NOX1, CYBB PRKCI 2510/4885DYRK1A 3287/4885MAPT 2832/4885
US-20210395238-A1 NADPH OXIDASE 4 INHIBITORS NOX4, NOX1, CYBB PRKCI 2510/4885DYRK1A 3287/4885MAPT 2832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.