Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062614 | 0.71 | CCR2 (0.38) | SMN1; SMN2MEN1KMT2AMAPTHTT | |
| SCHEMBL6187142 | 0.71 | GRIN2B (0.37) | SMN1; SMN2MAPTGRIN2BCCR2 | |
| SCHEMBL4067819 | 0.71 | CCR2 (0.38) | SMN1; SMN2MEN1KMT2AMAPTHTT | |
| SCHEMBL3904043 | 0.71 | ALDH1A1 (0.36) | SMN1; SMN2CCR2 | |
| SCHEMBL14095714 | 0.70 | SMN1; SMN2 (0.33) | SMN1; SMN2MAPTGRIN2BCCR2 | |
| SCHEMBL5343015 | 0.69 | ALDH1A1 (0.39) | MEN1KMT2AMAPTCCR2 | |
| SCHEMBL13655734 | 0.69 | MAPK1 (0.33) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13655884 | 0.69 | BACE1 (0.35) | MEN1KMT2A | |
| SCHEMBL4976100 | 0.67 | NR1H2 (0.46) | — | |
| SCHEMBL4068506 | 0.67 | NR1H2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515724-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-10-21 | — | — | EP | disclosed |