SCHEMBL19500466

SCHEMBL19500466

COc1ccc(C(C)(C)c2ccc(OC(=O)c3ccc4cc(C(=O)Oc5ccc(C(C)(C)c6ccc(OC(=O)c7cccc(C(C)=O)c7)c(C)c6)cc5C)ccc4c3)c(C)c2)cc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.43
ALDH1A1 P00352 4/20 0.43
KMT2A Q03164 7/20 0.41
MEN1 O00255 5/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
KDM4E B2RXH2 3/20 0.40
TSHR P16473 2/20 0.40
HPGD P15428 1/20 0.40
HSD17B10 Q99714 1/20 0.40
LMNA P02545 2/20 0.38
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
CREBBP Q92793 1/20 0.38
NPC1 O15118 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
POLB P06746 2/20 0.38
USP2 O75604 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19500472 0.95 MAPT (0.44) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL12376992 0.94 MAPT (0.43) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL142010 0.94 KMT2A (0.43) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL14007585 0.92 MAPT (0.43) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL12404394 0.91 KMT2A (0.44) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL19500471 0.91 KMT2A (0.38) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL17695181 0.89 KMT2A (0.42) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL19500465 0.89 ALDH1A1 (0.40) MAPTALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL19500463 0.88 KMT2A (0.44) MAPTALDH1A1KMT2AMEN1HPGD
SCHEMBL18680260 0.86 L3MBTL1 (0.47) MAPTALDH1A1KMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10031431-B2 Electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2018-07-24 US disclosed
US-20170307989-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-10-26 US disclosed