Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.72 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.72 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.72 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.72 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.72 |
| ▸ | MAOA | P21397 | 1/20 | 0.70 |
| ▸ | CA12 | O43570 | 2/20 | 0.64 |
| ▸ | CA9 | Q16790 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | USP2 | O75604 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | F12 | P00748 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.61 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065914 | 0.85 | TSHR (0.71) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL1367996 | 0.85 | GRIN1 (0.79) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL1367953 | 0.85 | GRIN1 (0.79) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL569881 | 0.84 | GPR35 (1.00) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL3273927 | 0.83 | GRIN1 (0.74) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL980429 | 0.83 | MAOA (1.00) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL1808756 | 0.82 | MAOA (0.71) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL1368479 | 0.81 | TSHR (0.51) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL1367592 | 0.81 | TSHR (0.74) | GPR35CA12CA9ALDH1A1F12 | |
| SCHEMBL11484256 | 0.79 | MAOB (0.74) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | US | claimed |
| WO-2006132947-A2 | 3-ACYL COUMARINS, THIOCHROMONES AND QUINOLONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-12-14 | — | — | WO | claimed |
| US-8067461-B2 | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2006132947-A2 | 3-ACYL COUMARINS, THIOCHROMONES AND QUINOLONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | NQO2, NQO1, HCCS | GRIN1 4625/4885GRIN2A 4789/4885GRIN2B 4792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.