Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.78 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | USP2 | O75604 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | IL6 | P05231 | 1/20 | 0.50 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.50 |
| ▸ | GLUL | P15104 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13659803 | 0.99 | PGR (0.77) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL13659805 | 0.98 | PGR (0.79) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL13659800 | 0.95 | NR3C1 (0.81) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL13659798 | 0.93 | NR3C1 (0.76) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL12562913 | 0.93 | PGR (0.67) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL12562918 | 0.93 | PGR (0.66) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL13659796 | 0.92 | NR3C1 (0.76) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL13659801 | 0.92 | NR3C1 (0.85) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL12562939 | 0.92 | PGR (0.68) | PGRNR3C1HIF1ALMNACYP3A4 | |
| SCHEMBL11438434 | 0.92 | PGR (0.87) | PGRNR3C1HIF1ALMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264393-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NICOX S.A. (FR) | 2009-10-22 | — | — | US | disclosed |
| US-20090264394-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NICOX S.A. (FR) | 2009-10-22 | — | — | US | disclosed |
| US-20090258849-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NICOX S.A. | 2009-10-15 | — | — | US | disclosed |
| US-20080221073-A1 | Nitrooxy Derivatives of Glucocorticoids | NICOX S.A. (FR) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221073-A1 | Nitrooxy Derivatives of Glucocorticoids | NR3C1, NR3C2, NR5A1 | PGR 161/4885NR3C1 1/4885HIF1A 3438/4885 |
| US-20090264393-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NR3C1, NR3C2, NR5A1 | PGR 161/4885NR3C1 1/4885HIF1A 3438/4885 |
| US-20090264394-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NR3C1, NR3C2, NR5A1 | PGR 161/4885NR3C1 1/4885HIF1A 3438/4885 |
| US-20090258849-A1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NR3C1, NR3C2, NR5A1 | PGR 161/4885NR3C1 1/4885HIF1A 3438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.