Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13847988 | 0.87 | OPRM1 (0.38) | OPRD1OPRM1OPRK1 | |
| SCHEMBL14089364 | 0.78 | HCRTR1 (0.38) | HCRTR1OPRD1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL14204835 | 0.77 | HCRTR1 (0.37) | HCRTR1OPRD1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL18473622 | 0.76 | HCRTR1 (0.40) | HCRTR1OPRD1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL13962904 | 0.75 | OPRM1 (0.37) | OPRD1OPRM1OPRK1CYP2D6 | |
| SCHEMBL12826657 | 0.74 | HCRTR1 (0.41) | HCRTR1OPRD1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL20170680 | 0.74 | HCRTR1 (0.38) | HCRTR1OPRD1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL10223357 | 0.72 | HCRTR1 (0.43) | HCRTR1OPRM1 | |
| SCHEMBL13847990 | 0.71 | OPRM1 (0.33) | OPRD1OPRM1OPRK1 | |
| SCHEMBL14161036 | 0.71 | OPRK1 (0.34) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132313-A2 | MORPHINAN DERIVATIVES OF ORGANIC AND INORGANIC ACIDS | PROGENICS PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |