Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170855 | 0.91 | HCRTR1 (0.35) | HCRTR1OPRM1OPRD1OPRK1HTR1A | |
| SCHEMBL18473622 | 0.86 | HCRTR1 (0.40) | HCRTR1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL12826657 | 0.85 | HCRTR1 (0.41) | HCRTR1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL14617397 | 0.83 | HTR1A (0.33) | OPRM1OPRD1OPRK1CYP2D6HSD17B10 | |
| SCHEMBL19937935 | 0.82 | OPRM1 (0.38) | OPRM1OPRD1OPRK1CYP2D6HSD17B10 | |
| SCHEMBL20170745 | 0.82 | HCRTR1 (0.42) | HCRTR1OPRM1OPRD1OPRK1HTR1A | |
| SCHEMBL12830849 | 0.78 | OPRM1 (0.38) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL14089364 | 0.77 | HCRTR1 (0.38) | HCRTR1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL14204835 | 0.77 | HCRTR1 (0.37) | HCRTR1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL10222575 | 0.76 | OPRM1 (0.37) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |