Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | USP14 | P54578 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | LCAT | P04180 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660459 | 0.88 | PDE4B (0.46) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL13660312 | 0.87 | PDE4B (0.43) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL13660461 | 0.86 | HRH3 (0.37) | PDE4BPDE4DUSP14HRH3 | |
| SCHEMBL3169708 | 0.82 | PDE4B (0.44) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL3169713 | 0.82 | PDE4B (0.44) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL13660412 | 0.82 | HRH3 (0.40) | PDE4BPDE4DUSP14HRH3 | |
| SCHEMBL13660313 | 0.79 | PDE4B (0.44) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL13660413 | 0.78 | DPP4 (0.34) | PDE4BPDE4DUSP14OPRM1OPRL1 | |
| SCHEMBL13985419 | 0.77 | PDE4B (0.34) | PDE4BPDE4DUSP14HRH3OPRM1 | |
| SCHEMBL13660463 | 0.73 | PDE4B (0.37) | PDE4BPDE4DUSP14HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |