Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | USP14 | P54578 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660457 | 0.88 | DPP4 (0.34) | DPP4SMN1; SMN2PDE4BPDE7A | |
| SCHEMBL13660414 | 0.87 | SMN1; SMN2 (0.34) | SMN1; SMN2PDE4BPDE7AGRM1 | |
| SCHEMBL13985419 | 0.78 | PDE4B (0.34) | DPP4USP14PDE4BPDE4DOPRM1 | |
| SCHEMBL13660309 | 0.78 | PDE4B (0.43) | USP14PDE4BPDE4DOPRM1OPRL1 | |
| SCHEMBL13660453 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2PDE4BPDE7AGRM1 | |
| SCHEMBL13660351 | 0.74 | SMN1; SMN2 (0.34) | SMN1; SMN2PDE4BPDE7AGRM1 | |
| SCHEMBL3169334 | 0.72 | PDE4B (0.33) | SMN1; SMN2PDE4BPDE7A | |
| SCHEMBL3169324 | 0.72 | PDE4B (0.33) | SMN1; SMN2PDE4BPDE7A | |
| SCHEMBL13660314 | 0.69 | PDE4B (0.34) | DPP4USP14PDE4BPDE4D | |
| SCHEMBL4755607 | 0.68 | PDE4B (0.34) | DPP4USP14PDE4BPDE4DOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |