Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | USP14 | P54578 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660459 | 0.84 | PDE4B (0.46) | PDE4BPDE4DUSP14PDE4AHRH3 | |
| SCHEMBL13660311 | 0.83 | HRH3 (0.40) | PDE4BPDE4DPDE4AHRH3PIK3CD | |
| SCHEMBL13660460 | 0.82 | PDE4B (0.39) | PDE4BPDE4DUSP14PDE4AHRH3 | |
| SCHEMBL13660309 | 0.79 | PDE4B (0.43) | PDE4BPDE4DUSP14PDE4AHRH3 | |
| SCHEMBL13660312 | 0.79 | PDE4B (0.43) | PDE4BPDE4DUSP14PDE4AHRH3 | |
| SCHEMBL3169708 | 0.78 | PDE4B (0.44) | PDE4BPDE4DUSP14PDE4AHRH3 | |
| SCHEMBL3169713 | 0.78 | PDE4B (0.44) | PDE4BPDE4DUSP14PDE4AHRH3 | |
| SCHEMBL4755652 | 0.77 | PDE4B (0.35) | PDE4BPDE4DUSP14PIK3CAJAK2 | |
| SCHEMBL13660310 | 0.66 | HRH3 (0.42) | PDE4BPDE4DHRH3PIK3CD | |
| SCHEMBL3177174 | 0.65 | PDE4B (0.42) | PDE4BPDE4DUSP14PDE4AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |