Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | USP14 | P54578 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660309 | 0.88 | PDE4B (0.43) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL13660312 | 0.88 | PDE4B (0.43) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL13660313 | 0.84 | PDE4B (0.44) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL3169708 | 0.84 | PDE4B (0.44) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL3169713 | 0.84 | PDE4B (0.44) | PDE4BPDE4DUSP14HRH3PDE4A | |
| SCHEMBL13660310 | 0.81 | HRH3 (0.42) | PDE4BPDE4DHRH3PIK3CDTSHR | |
| SCHEMBL13660416 | 0.81 | HRH3 (0.42) | PDE4BPDE4DUSP14HRH3PIK3CD | |
| SCHEMBL13660461 | 0.73 | HRH3 (0.37) | PDE4BPDE4DUSP14HRH3 | |
| SCHEMBL13660463 | 0.73 | PDE4B (0.37) | PDE4BPDE4DUSP14HRH3 | |
| SCHEMBL3174425 | 0.70 | PDE4B (0.36) | PDE4BPDE4DUSP14HRH3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |