Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660413 | 0.87 | DPP4 (0.34) | SMN1; SMN2PDE4BPDE7AGRM1 | |
| SCHEMBL13660351 | 0.86 | SMN1; SMN2 (0.34) | SMN1; SMN2PDE4BPDE7ACHRNB2CHRNA4 | |
| SCHEMBL3169334 | 0.84 | PDE4B (0.33) | SMN1; SMN2PDE4BPDE7ACHRNB2CHRNA4 | |
| SCHEMBL3169324 | 0.84 | PDE4B (0.33) | SMN1; SMN2PDE4BPDE7ACHRNB2CHRNA4 | |
| SCHEMBL13660457 | 0.83 | DPP4 (0.34) | SMN1; SMN2PDE4BPDE7A | |
| SCHEMBL13660308 | 0.80 | CHRNB2 (0.31) | CHRNB2CHRNA4 | |
| SCHEMBL13660453 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2PDE4BPDE7AGRM1POLB | |
| SCHEMBL13660461 | 0.76 | HRH3 (0.37) | PDE4BCHRNB2CHRNA4CYP11B2POLB | |
| SCHEMBL4756478 | 0.76 | CHRNB2 (0.36) | CHRNB2CHRNA4CYP11B2POLB | |
| SCHEMBL13985504 | 0.76 | CHRNB2 (0.36) | CHRNB2CHRNA4CYP11B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |