Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | GSR | P00390 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3169614 | 0.91 | DRD1 (0.37) | DRD1DRD5POLBSPRPI4KB | |
| SCHEMBL3169620 | 0.91 | DRD1 (0.37) | DRD1DRD5POLBSPRPI4KB | |
| SCHEMBL13660462 | 0.85 | POLB (0.34) | DRD1DRD5POLBPI4KBGRM1 | |
| SCHEMBL13660314 | 0.82 | PDE4B (0.34) | SPR | |
| SCHEMBL13660456 | 0.79 | HRH3 (0.40) | DRD1DRD5KCNH2 | |
| SCHEMBL4753376 | 0.78 | DRD1 (0.41) | DRD1DRD5POLBSPRGRM1 | |
| SCHEMBL4755057 | 0.78 | DRD1 (0.41) | DRD1DRD5POLBGRM1KCNH2 | |
| SCHEMBL13985519 | 0.78 | DRD1 (0.41) | DRD1DRD5POLBGRM1KCNH2 | |
| SCHEMBL4514625 | 0.76 | DRD1 (0.38) | DRD1DRD5POLBGRM1GRM5 | |
| SCHEMBL13985303 | 0.76 | DRD1 (0.39) | DRD1DRD5POLBGRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009121036-A2 | SUBSTITUTED ARYL PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |