Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660679 | 0.83 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL13890772 | 0.77 | HDAC1 (0.41) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL12900844 | 0.76 | ADCY5 (0.50) | ADORA2AADORA1ADORA2BADCY5KDR | |
| SCHEMBL8649567 | 0.74 | CKS1B (0.40) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL23453046 | 0.73 | TMIGD3 (0.40) | PDE4APDE4BPDE4CPDE4DHDAC1 | |
| SCHEMBL6803680 | 0.72 | TDP1 (0.40) | PDE4APDE4BPDE4CPDE4DDOT1L | |
| SCHEMBL6046940 | 0.72 | HDAC1 (0.43) | HDAC1TDP1FLT4KDR | |
| SCHEMBL14450500 | 0.72 | ADCY5 (0.48) | ADORA2AADORA1ADORA2BADCY5KDR | |
| SCHEMBL21253603 | 0.71 | ADCY5 (0.48) | ADORA2AADORA1ADORA2BADCY5 | |
| SCHEMBL23453050 | 0.71 | TDP1 (0.40) | PDE4APDE4BPDE4CPDE4DHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258381-A1 | Methods for Determining the Cleavability of Substrates | FORSCHUNGSZENTRUM BORSTEL (DE) | 2009-10-15 | — | — | US | disclosed |
| US-20090104633-A1 | Kit for Highly Sensitive Detection Assays | VYZKUMNY USTAV VETERINARNIHO LEKARSTVI (CZ) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258381-A1 | Methods for Determining the Cleavability of Substrates | CTSF, ADAM17, ADAM10 | PDE4A 3741/4885PDE4B 3669/4885PDE4C 3694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.