Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606114 | 0.92 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE4BPDE3APDE4APDE4C | |
| SCHEMBL1178300 | 0.87 | PTPN1 (0.36) | PTPN1PARP1 | |
| SCHEMBL13660729 | 0.87 | PGR (0.43) | SMN1; SMN2PDE4BPDE3APDE4APDE4C | |
| SCHEMBL7605856 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2PDE4BPDE3APDE4APDE4C | |
| SCHEMBL13660725 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2PDE4BPDE3APDE4APDE4C | |
| SCHEMBL7605706 | 0.83 | PARP1 (0.48) | SMN1; SMN2PDE4BPDE3APDE4APDE4C | |
| SCHEMBL12872074 | 0.82 | PTGES (0.43) | SMN1; SMN2PDE4BPDE3APDE4APDE4C | |
| SCHEMBL1178693 | 0.81 | MAOB (0.33) | PARP1 | |
| SCHEMBL1081126 | 0.81 | PTGES (0.40) | PARP1 | |
| SCHEMBL7602037 | 0.79 | PTGES (0.47) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127338-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-10-22 | — | — | WO | disclosed |