Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 5/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.39 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RHOC | P08134 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13664478 | 0.95 | BRD4 (0.36) | ACSS2CHRM4MAPTGAAPOLB | |
| SCHEMBL13664435 | 0.86 | RHOC (0.43) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664477 | 0.85 | KDM4E (0.38) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664373 | 0.85 | POLB (0.46) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664143 | 0.85 | POLB (0.46) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664437 | 0.85 | RHOC (0.43) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664413 | 0.84 | NPC1 (0.45) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664389 | 0.84 | DRD3 (0.42) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664403 | 0.83 | L3MBTL1 (0.46) | MAPTGAAPOLBTDP1L3MBTL1 | |
| SCHEMBL13664484 | 0.83 | MAPT (0.40) | MAPTGAAPOLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253673-A1 | Substituted Pyrazoles as Ghrelin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-08 | — | — | US | disclosed |
| US-20090253673-A1 | Substituted Pyrazoles as Ghrelin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253673-A1 | Substituted Pyrazoles as Ghrelin Receptor Antagonists | GIPR, GPR119, GLP1R | ACSS2 727/4885CHRM4 2371/4885TPSAB1 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.