Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13664696 | 0.89 | HTT (0.56) | HTTLMNASMN1; SMN2CA1CA2 | |
| SCHEMBL12197317 | 0.88 | POLB (0.59) | ALDH1A1LMNACA2POLBTSHR | |
| SCHEMBL7268833 | 0.88 | HTT (0.55) | HTTLMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL7268829 | 0.88 | HTT (0.55) | HTTLMNASMN1; SMN2CTSLCTSB | |
| SCHEMBL12197316 | 0.84 | POLB (0.58) | ALDH1A1LMNACA2POLBTSHR | |
| SCHEMBL2059433 | 0.82 | HTT (0.58) | HTTLMNASMN1; SMN2CA1CA2 | |
| SCHEMBL7209805 | 0.82 | HTT (0.64) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL7270291 | 0.81 | CAPN1 (0.59) | HTTCTSLCTSBCTSSCTSK | |
| SCHEMBL7270294 | 0.81 | CAPN1 (0.59) | HTTCTSLCTSBCTSSCTSK | |
| SCHEMBL6821732 | 0.81 | ALDH1A1 (0.57) | ALDH1A1LMNACA2POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119528-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |