Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28645265 | 0.93 | LMNA (0.58) | HTTLMNASMN1; SMN2CA1CA2 | |
| SCHEMBL13664875 | 0.89 | HTT (0.58) | HTTLMNASMN1; SMN2CA1CA2 | |
| SCHEMBL7268833 | 0.87 | HTT (0.55) | HTTLMNASMN1; SMN2 | |
| SCHEMBL7268829 | 0.87 | HTT (0.55) | HTTLMNASMN1; SMN2 | |
| SCHEMBL22166825 | 0.82 | HTT (0.68) | HTTLMNASMN1; SMN2TGM2L3MBTL1 | |
| SCHEMBL2059433 | 0.81 | HTT (0.58) | HTTLMNASMN1; SMN2CA1CA2 | |
| SCHEMBL7209805 | 0.81 | HTT (0.64) | HTTLMNASMN1; SMN2TGM2KEAP1 | |
| SCHEMBL344091 | 0.81 | LMNA (0.50) | HTTLMNASMN1; SMN2CA1CA2 | |
| SCHEMBL344090 | 0.81 | LMNA (0.50) | HTTLMNASMN1; SMN2CA1CA2 | |
| SCHEMBL7270294 | 0.81 | CAPN1 (0.59) | HTTFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119528-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |