Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919231 | 0.84 | KMT2A (0.48) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL1279945 | 0.84 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL7218028 | 0.83 | ALDH1A1 (0.76) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL2221490 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL3553806 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL10153796 | 0.82 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL2955119 | 0.81 | KMT2A (0.62) | SMN1; SMN2ALDH1A1HPGDKDM4ENPSR1 | |
| SCHEMBL18702790 | 0.81 | ALDH1A1 (0.60) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL1384171 | 0.80 | NPC1 (0.74) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL7000350 | 0.80 | RAB9A (0.80) | SMN1; SMN2MAPK1ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103709163-B | Xanthine derivative, Preparation Method And The Use | 齐鲁制药有限公司 | 2016-12-21 | — | — | CN | disclosed |
| WO-2016014913-A1 | INDAZOLE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR MODULATORS AND USES THEREOF | INNOV17 LLC (US) | 2016-01-28 | — | — | WO | disclosed |
| CN-103709163-A | Xanthine derivative, preparation method thereof and uses thereof | QILU PHARMACEUTICAL CO LTD | 2014-04-09 | — | — | CN | disclosed |
| US-7605158-B2 | Carbamoyl-type benzofuran derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090209511-A1 | Benzofuran Derivatives | KAWAGUCHI TAKAYUKI | 2009-08-20 | — | — | US | disclosed |
| US-7531537-B2 | Benzofuran derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209511-A1 | Benzofuran Derivatives | F12, F2, F3 | SMN1; SMN2 3067/4885MAPK1 1404/4885ALDH1A1 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.