Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13665491 | 0.92 | MCHR1 (0.49) | HTR5AHTR6MCHR1 | |
| SCHEMBL13306557 | 0.91 | HTR5A (0.47) | HTR5AHTR6 | |
| SCHEMBL13242091 | 0.90 | HTR6 (0.54) | HTR5AHTR6 | |
| SCHEMBL13654586 | 0.89 | MCHR1 (0.43) | HTR5AHTR6MCHR1 | |
| SCHEMBL13665758 | 0.86 | HTR6 (0.56) | HTR6 | |
| SCHEMBL13654594 | 0.85 | MCHR1 (0.45) | HTR5AHTR6MCHR1 | |
| SCHEMBL13654440 | 0.85 | HRH1 (0.42) | HTR6MCHR1 | |
| SCHEMBL13665774 | 0.83 | MCHR1 (0.39) | HTR5AHTR6MCHR1 | |
| SCHEMBL13306236 | 0.83 | BAZ2B (0.44) | HTR5AMCHR1 | |
| SCHEMBL13242303 | 0.82 | HDAC1 (0.50) | HTR5AHTR6MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338447-B2 | Pyrido[3,4-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20090270412-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270412-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | HTR3B, HTR4, HTR2C | HTR5A 6/4885HTR6 10/4885MCHR1 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.