Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 8/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.76 |
| ▸ | GLA | P06280 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.76 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.66 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368289 | 0.89 | MEN1 (0.76) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL37883 | 0.88 | MAOA (0.76) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL2471214 | 0.88 | ALDH1A1 (1.00) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL11070463 | 0.86 | MEN1 (0.71) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL893210 | 0.86 | MEN1 (0.74) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL592707 | 0.86 | MEN1 (1.00) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8565684 | 0.86 | MEN1 (0.69) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1367700 | 0.86 | MAOA (0.78) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1368846 | 0.85 | MIF (0.73) | MIFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9238048 | 0.83 | MIF (0.68) | MIFALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067461-B2 | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2006132947-A2 | 3-ACYL COUMARINS, THIOCHROMONES AND QUINOLONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | NQO2, NQO1, HCCS | MIF 2517/4885ALDH1A1 617/4885HPGD 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.