Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10565737 | 0.77 | MAOA (0.55) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL1166469 | 0.72 | MAOA (0.55) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL1367303 | 0.72 | GPR35 (0.59) | ALDH1A1KDM4EMAPTLMNATDP1 | |
| SCHEMBL27681980 | 0.72 | MCL1 (0.50) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL1368024 | 0.72 | GPR35 (0.59) | ALDH1A1KDM4EMAPTLMNATDP1 | |
| SCHEMBL830939 | 0.72 | CA12 (0.47) | ALDH1A1HPGDKDM4EMAPTTDP1 | |
| SCHEMBL29415362 | 0.71 | TSHR (0.55) | ALDH1A1HPGDKDM4EMAPTLMNA | |
| SCHEMBL9006042 | 0.71 | GPR35 (0.39) | ALDH1A1HPGDKDM4EMAPTLMNA | |
| SCHEMBL77405 | 0.70 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EMAPTLMNA | |
| SCHEMBL3057669 | 0.70 | KDM4E (0.63) | ALDH1A1HPGDKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067461-B2 | 3-acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-11-29 | — | — | US | disclosed |