Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 10/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14604182 | 0.85 | DHODH (0.56) | DHODHMEN1KMT2AMAPTRAB9A | |
| SCHEMBL1908379 | 0.80 | DHODH (0.56) | DHODHMEN1KMT2AMAPTRAB9A | |
| SCHEMBL11185769 | 0.79 | MAPT (0.41) | KMT2AMAPTRAB9AALDH1A1NPSR1 | |
| SCHEMBL1375014 | 0.77 | DHODH (0.56) | DHODHMEN1KMT2AMAPTRAB9A | |
| SCHEMBL13607458 | 0.75 | HSP90AA1 (0.54) | MAPTRAB9AALDH1A1NPSR1NPC1 | |
| SCHEMBL22028701 | 0.75 | KDM4E (0.41) | KMT2AMAPTRAB9AALDH1A1GAA | |
| SCHEMBL14678422 | 0.75 | P2RX7 (0.47) | KMT2AMAPTRAB9AALDH1A1PKM | |
| SCHEMBL7281512 | 0.75 | DHODH (0.71) | DHODHMEN1KMT2AMAPTRAB9A | |
| SCHEMBL9487325 | 0.74 | TDP1 (0.59) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL14156047 | 0.74 | NAPRT (0.43) | KMT2AMAPTRAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608716-B2 | Pyrazolonaphthyridine derivative | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-10-27 | — | — | US | disclosed |