SCHEMBL136715

SCHEMBL136715

CC1(C)C(/C=C/C=C/Nc2ccccc2)=[N+](CCCS(=O)(=O)[O-])c2cccc(C(=O)O)c21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 1/20 0.43
HRH2 P25021 4/20 0.43
CHRM1 P11229 2/20 0.43
CHRM3 P20309 2/20 0.43
MLNR O43193 1/20 0.43
NR1I2 O75469 1/20 0.43
PGR P06401 1/20 0.43
ADRB1 P08588 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
DRD2 P14416 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
CNR1 P21554 1/20 0.43
DRD1 P21728 1/20 0.43
TBXA2R P21731 1/20 0.43
SLC6A2 P23975 1/20 0.43
HTR2C P28335 1/20 0.43
BDKRB2 P30411 1/20 0.43
ADORA1 P30542 1/20 0.43
AGTR1 P30556 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10111606 0.92 MLNR (0.42) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL10111599 0.85 MEN1 (0.41) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL136048 0.83 MEN1 (0.39) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL14812066 0.83 MEN1 (0.39) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL19976556 0.81 MLNR (0.38) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL15580858 0.81 MEN1 (0.43) MEN1KMT2AUSP2MAPTTHRB
SCHEMBL19052118 0.81 MLNR (0.38) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL19052121 0.80 MLNR (0.42) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL1715260 0.78 HRH2 (0.42) BLMHRH2CHRM1CHRM3MLNR
SCHEMBL1715259 0.78 HRH2 (0.42) BLMHRH2CHRM1CHRM3MLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240132948-A1 Cyanine Dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2024-04-25 US disclosed
US-11624089-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2023-04-11 US disclosed
US-20200232023-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2020-07-23 US disclosed
US-10392659-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2019-08-27 US disclosed
US-9920365-B2 Functionalized cyanine dyes (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2018-03-20 US disclosed
US-20170183501-A1 Cyanine Dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2017-06-29 US disclosed
US-9441270-B2 Cyanine dyes PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2016-09-13 US disclosed
US-20150344950-A1 Functionalized Cyanine Dyes (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2015-12-03 US disclosed
US-9051263-B2 Functionalized cyanine dyes (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2015-06-09 US disclosed
US-20150072894-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2015-03-12 US disclosed
US-8889886-B2 Cyanine dyes PACIFIC BIOSCIENCES, INC. (US) 2014-11-18 US disclosed
US-8669374-B2 Functionalized cyanine dyes (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 2014-03-11 US disclosed
US-20120058469-A1 FUNCTIONALIZED CYANINE DYES (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-08 US disclosed
US-20120058482-A1 FUNCTIONALIZED CYANINE DYES (PEG) PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-08 US disclosed
US-20120052506-A1 CYANINE DYES PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-03-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132948-A1 Cyanine Dyes ABCG2, IK, ACR BLM 3964/4885HRH2 4138/4885CHRM1 1601/4885
US-10392659-B2 Cyanine dyes ABCG2, IK, ACR BLM 3964/4885HRH2 4138/4885CHRM1 1601/4885
US-11624089-B2 Cyanine dyes ABCG2, IK, ACR BLM 3964/4885HRH2 4138/4885CHRM1 1601/4885
US-20120052506-A1 CYANINE DYES ABCG2, IK, ACR BLM 3964/4885HRH2 4138/4885CHRM1 1601/4885
US-20200232023-A1 CYANINE DYES ABCG2, IK, ACR BLM 3964/4885HRH2 4138/4885CHRM1 1601/4885
US-20120058482-A1 FUNCTIONALIZED CYANINE DYES (PEG) ACR, IK, EGFR BLM 4492/4885HRH2 4106/4885CHRM1 2004/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.