Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 6/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715259 | 1.00 | HRH2 (0.42) | HRH2CHRM1CHRM3MLNRNR1I2 | |
| SCHEMBL1658644 | 0.91 | PTPN1 (0.41) | HRH2CHRM1CHRM3MLNRNR1I2 | |
| SCHEMBL1658645 | 0.91 | PTPN1 (0.41) | HRH2CHRM1CHRM3MLNRNR1I2 | |
| SCHEMBL7018706 | 0.90 | PTPN1 (0.41) | HRH2CHRM1CHRM3MLNRNR1I2 | |
| SCHEMBL14404492 | 0.90 | PTPN1 (0.41) | HRH2CHRM1CHRM3MLNRNR1I2 | |
| SCHEMBL1714460 | 0.89 | PRMT1 (0.45) | HRH2CHRM1CHRM3MLNRNR1I2 | |
| SCHEMBL1714462 | 0.89 | PRMT1 (0.45) | HRH2CHRM1CHRM3MLNRNR1I2 | |
| SCHEMBL3824520 | 0.89 | FOLH1 (0.41) | HRH2CHRM1CHRM3ADORA1OPRK1 | |
| SCHEMBL12952135 | 0.89 | FOLH1 (0.41) | HRH2CHRM1CHRM3ADORA1OPRK1 | |
| SCHEMBL3824519 | 0.89 | FOLH1 (0.41) | HRH2CHRM1CHRM3ADORA1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044203-B2 | Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups | CARNEGIE MELLON UNIVERSITY (US) | 2011-10-25 | — | — | US | disclosed |
| EP-1525265-B1 | CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS | UNIV CARNEGIE MELLON (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2258776-A1 | Fluorescent cyanine dyes containing functional groups | CARNEGIE MELLON UNIVERSITY (US) | 2010-12-08 | — | — | EP | disclosed |
| US-20100267008-A1 | CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS | CARNEGIE MELLON UNIVERSITY (US) | 2010-10-21 | — | — | US | disclosed |
| US-7615646-B2 | Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups | CARNEGIE MELLON UNIVERSITY (US) | 2009-11-10 | — | — | US | disclosed |
| US-20060051758-A1 | Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-03-09 | — | — | US | disclosed |
| EP-1525265-A4 | CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS | UNIV CARNEGIE MELLON (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1525265-A2 | CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS | CARNEGIE-MELLON UNIVERSITY (US) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004039894-A2 | CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS | CARNEGIE MELLON UNIVERSITY (US) | 2004-05-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060051758-A1 | Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups | IDO1, TDO2, IDO2 | HRH2 3995/4885CHRM1 319/4885CHRM3 247/4885 |
| US-20100267008-A1 | CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS | IDO1, IDO2, INMT | HRH2 4111/4885CHRM1 367/4885CHRM3 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.