Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672438 | 0.85 | MAPK1 (0.39) | KDM4EKMT2ALMNACYP2C19MAPT | |
| SCHEMBL1750234 | 0.85 | MAPT (0.45) | NPSR1KDM4EKMT2ALMNACYP2C19 | |
| SCHEMBL2207714 | 0.84 | NPSR1 (0.34) | NPSR1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL1750708 | 0.83 | MAPK1 (0.47) | KDM4EKMT2AMAPTPOLBRXFP1 | |
| SCHEMBL1749829 | 0.82 | MAPK1 (0.49) | KDM4EKMT2AMAPTPOLBRXFP1 | |
| SCHEMBL2206374 | 0.80 | ALDH1A1 (0.40) | NPSR1KDM4EKMT2AMAPTPOLB | |
| SCHEMBL2208594 | 0.79 | NR1H2 (0.44) | LMNAMAPTPOLBALDH1A1USP2 | |
| SCHEMBL2206687 | 0.74 | NPSR1 (0.32) | NPSR1ERCC1FEN1ERCC4KDM4C | |
| SCHEMBL12511105 | 0.73 | LMNA (0.33) | KDM4EKMT2ALMNACYP2C19MAPT | |
| SCHEMBL13953756 | 0.69 | ALDH1A1 (0.40) | NPSR1KDM4EPOLBERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253681-A1 | HIV Integrase Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253681-A1 | HIV Integrase Inhibitors | REV1, INTS9, H1-10 | NPSR1 3466/4885KDM4E 1040/4885KMT2A 1004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.