Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | SGK1 | O00141 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.36 |
| ▸ | CTPS1 | P17812 | 5/20 | 0.35 |
| ▸ | CTPS2 | Q9NRF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391735 | 0.91 | KIT (0.48) | KITALOX5APFEN1KIF11KDM1A | |
| SCHEMBL13672516 | 0.91 | KIT (0.39) | KITALOX5APFEN1MAP2K1BRAF | |
| SCHEMBL392187 | 0.90 | ACLY (0.47) | KITALOX5APFEN1ACLYMAP2K1 | |
| SCHEMBL388038 | 0.88 | CKS1B (0.43) | KITALOX5APFEN1KIF11BRAF | |
| SCHEMBL391267 | 0.87 | KIF11 (0.46) | KITALOX5APFEN1SGK1KIF11 | |
| SCHEMBL392469 | 0.86 | ACLY (0.40) | KITALOX5APFEN1KIF11ACLY | |
| SCHEMBL16015383 | 0.84 | KIT (0.39) | KITALOX5APFEN1ACLYBRAF | |
| SCHEMBL387133 | 0.84 | DHODH (0.42) | KITALOX5APFEN1KIF11BRAF | |
| SCHEMBL387927 | 0.83 | MAP2K1 (0.44) | KITMAP2K1BRAFMAP2K2 | |
| SCHEMBL391195 | 0.82 | KIT (0.41) | KITALOX5APFEN1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009129246-A2 | COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME | ARDEA BIOSCIENCES, INC. (US) | 2009-10-22 | — | — | WO | disclosed |