Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912380 | 0.85 | TBXAS1 (0.69) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL12833646 | 0.85 | LMNA (0.57) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL2236453 | 0.84 | MAPT (0.73) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL12833642 | 0.83 | TBXAS1 (0.57) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL12761935 | 0.82 | TBXAS1 (0.60) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL29906409 | 0.82 | TBXAS1 (0.60) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL12761938 | 0.81 | TBXAS1 (0.59) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL12833639 | 0.81 | TBXAS1 (0.59) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL5731336 | 0.81 | TDP1 (0.43) | LMNAALDH1A1MAPTHTTKDM4E | |
| SCHEMBL10956396 | 0.80 | KDM4E (0.63) | LMNAALDH1A1MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257515-B1 | 1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NAT RECH SCIENT (FR) | 2017-05-17 | — | — | EP | disclosed |
| US-9090549-B2 | 1,4-naphthoquinones derivatives and therapeutic use thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2015-07-28 | — | — | US | disclosed |
| WO-2009118327-A1 | 1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-01 | — | — | WO | disclosed |