Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433867 | 0.89 | SMN1; SMN2 (0.60) | MEN1KMT2APOLBCYP1A2CYP3A4 | |
| SCHEMBL14300432 | 0.80 | NPC1 (0.60) | MEN1KMT2APOLBCYP1A2CYP3A4 | |
| SCHEMBL2739995 | 0.78 | MAPT (0.65) | MEN1KMT2APOLBMAPTTP53 | |
| SCHEMBL12205437 | 0.77 | KCNK3 (0.67) | MEN1KMT2APOLBMAPTTP53 | |
| SCHEMBL5328182 | 0.77 | RAB9A (0.71) | MEN1KMT2APOLBMAPTTP53 | |
| SCHEMBL23846564 | 0.77 | HCRTR1 (0.50) | MEN1KMT2APOLBMAPTTP53 | |
| SCHEMBL14274810 | 0.76 | SMN1; SMN2 (0.57) | MEN1KMT2APOLBCYP1A2CYP3A4 | |
| SCHEMBL3938751 | 0.76 | FBP1 (0.55) | MEN1KMT2APOLBCYP3A4MAPT | |
| SCHEMBL28922759 | 0.75 | RAB9A (0.66) | MEN1KMT2AMAPTTP53PGR | |
| Bromide SCHEMBL8360818 | 0.75 | RAB9A (0.69) | MEN1KMT2APOLBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605264-B2 | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-10-20 | — | — | US | disclosed |